Tampons and Toxic Shock Syndrome

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Richard Dicker and Ruth Berkelman
Date published
Jan, 1983
Last updated
31 Jan 2020


The initial outbreak investigations of toxic shock syndrome in 1980 using a series of matched case-control studies. Case study focuses on matching, secondarily on surveillance.  


  • Describe the concepts, applications, and limitations of matching in case-control studies
  • Analyze matched case-control data
  • Discuss the issues involved in appropriate selection of controls in case-control studies